A new baby in the c-Myc-directed transcriptional machinery: Che-1/AATF |
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| Authors: | Valentina Folgiero Cristina Sorino Franco Locatelli Maurizio Fanciulli |
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| Affiliation: | 1. Department of Pediatric Hematology/Oncology and of Cell and Gene Therapy, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy;2. SAFU, Department of Research, Advanced Diagnostics, and Technological Innovation, Translational Research Area, Regina Elena National Cancer Institute, Rome, Italy;3. Department of Pediatric Science, University of Pavia, Pavia, Italy |
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| Abstract: | B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is the most common malignancy in childhood. Despite the high cure-rate, identifying new druggable molecular targets is still of great interest. In a cohort of BCP-ALL pediatric patients, irrespectively of the molecule/karyotype lesions found, we recently observed high expression of c-Myc and Che-1/AATF, which disappears at time of remission. Study of the molecular mechanisms involved in this co-expression revealed that Che-1 expression was crucial for induction of blast-cell proliferation driven by c-Myc. Furthermore, Che-1/AATF silencing in primary BCP-ALL cell lines improves responsiveness to chemotherapy. These data individuate Che-1 as a possible novel target in the treatment of BCP-ALL able to affect c-Myc-driven tumorigenicity. |
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| Keywords: | Che-1 c-Myc BCP-ALL |
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