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Discovery of anti-influenza A virus activity of a corynanthe-type indole alkaloid, hirsutine, in vitro and the structure-activity relationship of natural and synthetic analogs |
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| Authors: | Hiromitsu Takayama Yasuo Iimura Mariko Kitajima Norio Aimi Kenji Konno Hiroshi Inoue Masatoshi Fujiwara Tadashi Mizuta Tomoyuki Yokota Shiro Shigeta Kenji Tokuhisa Yasuaki Hanasaki Kimio Katsuura |
| Affiliation: | a Faculty of Pharmaceutical Sciences, Chiba University, 1–33, Yayoi-cho, Inage-ku, Chiba 263, Japan b Rational Drug Design Laboratories, Fukushima 960-12, Japan c Department of Microbiology, Fukushima Medical College, Fukushima 960-12, Japan d Tokyo Research Laboratory, Tosoh Corporation, 2743-1, Hayakawa, Ayase, Kanagawa 252, Japan |
| Abstract: | An indole alkaloid, hirsutine (1), was found to exhibit potent inhibitory effect against influenza A virus in vitro, and the essential structural feature for revealing the activity was elucidated by study of the structure-activity relationship using natural and synthetic derivatives of 1. |
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