c-fos and c-myc expression in human endothelial cells as a function of different culture conditions |
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| Authors: | M G Lampugnani N Polentarutti M Pedenovi A Mantovani E Dejana F Colotta |
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| Affiliation: | Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy. |
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| Abstract: | Cultured human umbilical vein endothelial cells (HEC) could be induced to express c-fos and c-myc mRNA by either serum or ECGS (endothelial cell growth supplement). Neither agonist separately could support HEC proliferation but the combination did. Expression of c-fos and c-myc mRNA in the presence of both serum and ECGS was similar to that observed after each of the two stimuli was introduced separately. c-fos and c-myc expression in cultured HEC, even if related, is not necessarily accompanied by stimulation of cell growth. |
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