| B淋巴细胞刺激因子（BLyS）研究进展 |
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| 引用本文： | 吴一凡,张双全. B淋巴细胞刺激因子（BLyS）研究进展[J]. 生物化学与生物物理进展, 2001, 28(5): 658-661 |
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| 作者姓名： | 吴一凡 张双全 |
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| 作者单位： | 南京师范大学生命科学学院南京210097 |
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| 摘 要： | B淋巴细胞刺激因子（BLyS）是1999年新发现的一种重要的细胞因子，属于肿瘤坏死因子(TNF)超家族成员.在体液免疫调控中起重要作用.它能强烈地刺激B淋巴细胞的增殖和分化并分泌大量免疫球蛋白(主要为IgM)；在体外其过量表达能促进多种B系肿瘤细胞的生长.BLyS转基因小鼠出现严重的红斑狼疮样症状.对BLyS的基因和蛋白质结构、免疫调控功能、受体和信号通路及其在自身免疫性疾病和恶性肿瘤中的作用进行了综述.
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| 关 键 词： | B淋巴细胞刺激因子（BLyS），细胞增殖，体液免疫，受体，自身免疫性疾病 |
| 收稿时间： | 2000-12-19 |
| 修稿时间： | 2000-12-19 |
Progress on B Lymphocyte Stimulator (BLyS) |
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| WU Yi-Fan and ZHANG Shuang-Quan. Progress on B Lymphocyte Stimulator (BLyS)[J]. Progress In Biochemistry and Biophysics, 2001, 28(5): 658-661 |
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| Authors: | WU Yi-Fan and ZHANG Shuang-Quan |
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| Affiliation: | Laboratory of Biochemistry and Molecular Biology,Nanjing Normal University, Nanjing 210097, China;Laboratory of Biochemistry and Molecular Biology,Nanjing Normal University, Nanjing 210097, China |
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| Abstract: | B lymphocyte stimulator (BLyS) is a recently identified member of the tumor necrosis factor (TNF) superfamily that costimulates B lymphocyte proliferation and differentiation. It prominently enhances the humoral responses to both T cell-independent and T cell-dependent antigens. BLyS is required to sustain proliferation of splenic germinal center (GC) B cell in vivo. As an antiapoptotic cytokine, BLyS provides survival signals by inducing up-regulation of Bcl-2. Transgenic mice overexpressing BLyS in lymphoid cells develops symptoms characteristic of systemic lupus erythaematosus (SLE). |
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| Keywords: | B lymphocyte stimulator (BLyS) cell proliferation humoral immunity receptors autoimmune disease |
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