Ionic mechanism of a voltage-dependent current elicited by cyclic AMP |
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Authors: | Terry C Pellmar |
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Institution: | (1) Physiology Department, Armed Forces Radiobiology Research Institute, 20014 Bethesda, Maryland, USA;(2) Present address: 12501 Washington Ave, NIAAA, 20852 Rockville, Maryland, USA |
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Abstract: | Intracellular pressure injection of cyclic AMP induces a slow voltage-dependent inward current in some neurons of Aplysia californica.The time course, voltage dependence, and ionic sensitivities of this response are nearly identical to those of the voltage-dependent calcium current induced by serotonin in the same preparation. The response to cyclic AMP is unaffected by changes in the extracellular concentration of chloride or potassium. The current is slowly but minimally reduced by a sodium-free solution. The calcium channel blocker, cadmium, blocks the current elicited by injection of cyclic AMP. The data presented here suggest that cyclic AMP can induce a voltage-dependent calcium current. |
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Keywords: | cyclic AMP calcium serotonin voltage-dependent current Aplysia |
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