A vaccine strategy utilizing a combination of three different chimeric vectors which share specific vaccine antigens |
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| Authors: | Jonathan L. Heeney,Gerrit Koopman,Brigitte Rosenwirth,Willy Bogers,Jeanette van Dijk,Ivonne Nieuwenhuis,Henk Niphuis,Peter ten Haaft,Thomas Hanke,Gary Rhodes,Peter Berglund,Arsene Burny,Francoise Bex,Gerd Sutter,& Peter Liljeströ m |
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| Affiliation: | Biomedical Primate Research Centre, Department of Virology, Rijswijk, The Netherlands;;John Radcliffe Hospital, Institute of Molecular Medicine, Molecular Immunology Group, University of Oxford, UK;;University of California, Department of Medical Pathology, Davis, USA;;Microbiology and Tumor Biology Centre, Karolinska Institute, Stockholm, Sweden;;Universitéde Bruxelles, Laboratoire de Chimie Biologique, Rhode-Saint-Genese, Belgium;;GSF-Forschungszentrum für Umwelt und Gesundheit GmbH, Institut für Molekulare Virologie, München, Germany;;Department of Vaccine Research, Swedish Institute for Infectious Disease Control, Stockholm, Sweden |
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| Abstract: | A large number of recombinant of viral and bacterial systems have been engineered as vectors to express foreign genes for vaccination and/or gene therapy. A common problem is the immune response to the vector itself. The presence of anti-vector immune responses may preclude sufficient 'priming' or immunogenicity if pre-existing immune responses are present, or they may impair optimal 'boosting' upon repeated immunization or delivery with the same vector. To circumvent this problem we developed a strategy using different chimeric vectors which share only the expression of common specific antigens desired for immunization. This approach not only has the advantage of avoiding increased anti-vector responses, but allows the use of combinations of vectors which could subsequently present the same or related antigen differently to the immune system as well as at alternative sites to induce the optimal type of immunity against the pathogen of interest. |
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| Keywords: | AIDS vaccine delivery systems effective immunization SIV |
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