Vacuolar proteases livening up programmed cell death |
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Authors: | Lam Eric |
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Institution: | Biotech Center, Rutgers University, 59 Dudley Road, Foran Hall, New Brunswick, NJ 08901, USA. Lam@aesop.rutgers.edu |
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Abstract: | The molecular identity of the key executioners involved in controlling plant programmed cell death (PCD) has been elusive. In a recent paper published in Science, Hatsugai and coworkers reported that a well-characterized protease called VPE from the plant cell vacuole can cleave caspase-specific substrates and is required for cell death activation by tobacco mosaic virus. This work provides clear evidence for the importance of the vacuole in plant PCD and a novel regulatory function for this organelle as well as for VPE proteases. |
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