Regional and species differences in endogenous prostaglandin biosynthesis by brain homogenates |
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| Authors: | M Saeed Abdel-Halim Erik ngga
rd |
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| Institution: | Department of Pharmacology and Department of Alcohol and Drug Addiction Research, Karolinska Institutet, 104 01 Stockholm, Sweden |
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| Abstract: | Endogenously formed prostaglandins (PGs) D2, E2 and F2α were determined in homogenates of brain regions from rat, guinea-pig, rabbit and cat, using gas-chromatography-mass spectrometry. The main PGs formed in the brain regions of the rat were PGD2, in the guinea-pig PGD2 and PGF2α, in the rabbit PGF2α and in the cat PGE2. Brain regions from the same animal species showed the same pattern of PG formation. They varied, however, in the amount of total PGs formed, the limbic system and the cerebral cortex being highest and cerebellum lowest. |
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