Effects of 5-(3,3-dimethyl-1-triazeno) imidazole-4-carboxamide [NSC 45388, DTIC] on neuroblastoma cells in culture. |
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| Authors: | B Culver S K Sahu A Vernadakis K N Prasad |
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| Affiliation: | Departments of Pharmacology, Psychiatry and Radiology University of Colorado School of Medicine 4200 East Ninth Avenue, Denver, Colorado 80262 USA |
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| Abstract: | The effects of 5-(3,3-dimethyl-1-triazeno) imidazole-4-carboximide (DTIC) on morphological and biochemical parameters of differentiation were studied in mouse neuroblastoma cells in culture. DTIC (10 μg/ml) did not induce formation of neurites in the cells but inhibited cell division, and produced a marked increase in cell size and in activity of three enzymes (tyrosine hydroxylase, choline acetyltransferase and acetylcholinesterase) involved in neurotransmitter metabolism. These effects were apparently not related to an increase in the intracellular level of cyclic AMP. |
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