| 白念珠菌V-ATPase研究进展 |
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| 引用本文： | 周密,;康烨,;阎澜,;姜远英. 白念珠菌V-ATPase研究进展[J]. 中国真菌学杂志, 2014, 0(3): 177-181 |
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| 作者姓名： | 周密, 康烨, 阎澜, 姜远英 |
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| 作者单位： | [1]第二军医大学药学院新药研究中心,上海200433; [2]沈阳军区总医院北陵临床部,沈阳110031 |
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| 摘 要： | 白念珠菌是临床最常见的条件致病真菌,V-ATPase是真核生物中高度保守的质子泵转运复合物,可以维持液泡和细胞质pH稳态.近年来,V-ATPase作为一个抗白念珠菌感染的潜在靶点为人们所关注,本文就V-ATPase抑制剂、相关的其他靶点及抑制剂筛选等方面的研究进展作一综述.
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| 关 键 词： | 白念珠菌 液泡 V-ATPase |
Progress of V-ATPase in Candida albicans |
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| Affiliation: | ZHOU Mi(New Drug R ＆ D Center,School of Pharmacy,Second Military Medical University,Shanghai 200433,China) KANG Ye(General Hospital of Shenyang Military Region, Beijing Clinical Department, Shenyang 110031, China) YAN Lan(New Drug R ＆ D Center,School of Pharmacy,Second Military Medical University,Shanghai 200433,China) JIANG Yuan-ying(New Drug R ＆ D Center,School of Pharmacy,Second Military Medical University,Shanghai 200433,China) |
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| Abstract: | Candida albicans is the most common opportunistic fungal pathogen in humans.V-ATPase is one of the proton transporter complexes,which is highly conserved in eukaryotes.V-ATPase sustains the pH steady between cytosolic and vacuolar.Recently V-ATPase has been concerned as a potential target in C.albicans.This article reviews its research progress. |
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| Keywords: | Candida albicans vacuole V-ATPase |
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