| 上海,无锡地区汉族人群HLADR4基因14种亚型分析 |
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| 引用本文： | 朱乃硕 王亚新. 上海,无锡地区汉族人群HLADR4基因14种亚型分析[J]. Acta biochimica et biophysica Sinica, 1995, 27(2): 193-199 |
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| 作者姓名： | 朱乃硕 王亚新 |
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| 作者单位： | 上海第二医科大学生物化学教研室，复旦大学生命科学院病毒室，上海市免疫学研究所免疫Ⅱ室 |
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| 摘 要： | 本文应用聚合酶链反应配合限制性内切酶片段长度多态性（ＰＣＲ－ＲＦＬＰ）分析方法，在１３０例上海、无锡地区汉族人群中发现２３例ＤＲ４基因检测呈阳性，对其ＤＲ４基因的亚型ＲＦＬＰ和分布频率特征进行了研究，结果显示，ＤＲ４基因携带者为１７．７％，存在７种ＤＲ４亚型，以ＤＲＢ１＊０４０５频率最高，构成ＤＲ４阳性人群的４７．８％，其次为ＤＲＢ１＊０４０６和ＤＲＢ１＊０４０３，分别为２１．７％和１７．４％，上
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| 关 键 词： | 人类白细胞抗原 DR4基因亚型 人群 中国人群 |
Studies on Fourteen HLA DR_4 Subtypes in a Chinese Papulation from Shanghai and Wuxi |
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| ZHU Nai-Sho, WANG Ya-Xin, WANG FU-Qing and CHEN Shi-Shu. Studies on Fourteen HLA DR_4 Subtypes in a Chinese Papulation from Shanghai and Wuxi[J]. Acta biochimica et biophysica Sinica, 1995, 27(2): 193-199 |
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| Authors: | ZHU Nai-Sho WANG Ya-Xin WANG FU-Qing CHEN Shi-Shu |
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| Abstract: | The recently developed PCR-RFLP method was used to analyse the DR4,subtype in a random samples of 130 Chinese individuals in Shanghai and Wuxi cities.The results show that the frequency of DR4 positive carriers is 17.7%,and there are at least seven DR4 subtypes.Among the DR4 subtype,the frequency of DRB1*0405 is the highest,accounting for 47.8% in 23 cases of DR4 positive individuals.Another two major DR4 subtypes,DRB1*0406 and DRB1*0403,account for 21.7% and 17.4% respectively.The composition and frequency of DR4subtypes in Chinese people studied are quite different from those reported in other domestic and foreign ethnic groups.These data are important for organ transplantation matching, identification in forensic medicine,ethnology and the molecular basis of the DR4 associated autoimmune diseases. |
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| Keywords: | Human leucocyte antigen(HLA) DR4 gene subtype Chinese population PCR-RFLP |
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