Substituted propanolamines and alkylamines derived from fluoxetine as potent appetite suppressants |
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Authors: | Bhandari Kalpana Srivastava Shipra Shanker Girija Nath Chandishwar |
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Institution: | Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow 226 001, India. bhandarikalpana@rediffmail.com |
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Abstract: | A series of propanolamine and alkylamine analogues of fluoxetine (7-26, 28-31) were synthesized and assessed for their anorexigenic and antidepressant activities. Effect of various substituents at C-4 aryl position of fluoxetine has also been studied. Most of the propanolamine analogues (7-13, 16-26) displayed significant anorexigenic activity but interestingly they were devoid of antidepressant activity whereas anorexigenic as well as antidepressant activity was retained in the alkylamine series (28-31). Compounds 10 and 26 emerged as the most active compound and anorexigenic activity was better (83.67% and 82.45%) compared to fluoxetine (81.25%). |
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