Oncostatin-M inhibits luteinizing hormone stimulated Leydig cell progenitor formation in vitro |
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| Authors: | Katja J Teerds Federica MF van Dissel-Emiliani Maria P De Miguel Mieke de Boer-Brouwer Lina M Körting Eddy Rijntjes |
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| Affiliation: | (1) Department of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands;(2) Department of Animal Sciences, Human and Animal Physiology Group, Wageningen University, Wageningen, the Netherlands;(3) Cell Engineering Laboratory, La Paz Hospital, Madrid, Spain |
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| Abstract: | Background The initial steps of stem Leydig cell differentiation into steroid producing progenitor cells are thought to take place independent of luteinizing hormone (LH), under the influence of locally produced factors such as leukaemia inhibitory factor (LIF), platelet derived growth factor A and stem cell factor. For the formation of a normal sized Leydig cell population in the adult testis, the presence of LH appears to be essential. |
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