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Regional assignment of the human thymidylate synthase (TS) gene to chromosome band 18p11.32 by nonisotopic in situ hybridization |
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| Authors: | Tada-aki Hori Ei-ichi Takahashi Dai Ayusawa Keiichi Takeishi Sumiko Kaneda Takeshi Seno |
| Institution: | (1) Division of Genetics, National Institute of Radiological Sciences, 4-9-1, Anagawa, 260 Chiba, Japan;(2) Institute of Applied Microbiology, University of Tokyo, Bunkyoku, 113 Tokyo, Japan;(3) School of Food and Nutritional Sciences, University of Shizuoka, Yata, 422 Shizuoka, Japan;(4) Laboratory of Mutagenesis, National Institute of Genetics, Mishima, 411 Shizuoka, Japan |
| Abstract: | Summary The human thymidylate synthase (TS) gene was regionally assigned to chromosome band 18p11.32 by nonisotopic in situ hybridization using biotinylated cDNA (1.1kb insert) and genomic DNA (6.8kb insert) probes of the human gene. There have been two provisional assignments for the TS gene to 18pter-q12 and 18q21-qter. The present result confirmed the first of these and further localized the TS gene to the telomeric region of the short arm of chromosome 18. The TS gene appears to be a novel telomeric anchor point for the construction of both physical and genetic linkage maps of human chromosome 18. |
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