微生物与肺癌研究的知识图谱构建及可视化分析

【背景】微生物与肺癌的发生发展密切相关，该领域研究已成为国内外持续关注的焦点。【目的】对微生物与肺癌相关的文献进行文献计量分析，分析该领域的研究现状和发展趋势，为后续研究提供参考。【方法】收集Web of Science Core Collection （WOSCC）、中国知网（China National Knowledge Infrastructure，CNKI）、万方（Wanfang）与维普（VIP database for Chinese technical periodicals，VIP）等数据库的文献数据，并通过CiteSpace和VOSviewer对其年发文量、国家/地区、关键词进行可视化分析。【结果】共收录中文文献143篇，英文文献278篇。中国是发文量最多的国家。关键词分析显示，肺癌、肠道微生物、免疫治疗等关键词是该领域的研究热点。【结论】在过去20年中人们已关注到微生物在肺癌致病机制、诊断和治疗中的作用。通过对比这些数据库发现，国内外关注的热点话题基本一致。但该领域仍处于早期发展阶段，研究相对不成熟，缺乏广泛密切的国际合作，未来应进一步加强对该领域前沿热点的深入研究。本文结果有助于研究人员进一步了解该领域前沿热点及发展趋势，为后续研究的深入探索提供参考。

Knowledge graph construction and visualization of the associations between microbiota and lung cancer

Background] Microbiota is closely related to the occurrence and development of lung cancer, and the field of study has become a hotspot. Objective] This study seeks to conduct a comprehensive bibliometric analysis of the literature elucidating the associations between microbiota and lung cancer. Its aims include unveiling the present research status, identifying future trends, and offering a compass for subsequent investigations. Methods] Literature data were sourced from the Web of Science Core Collection (WOSCC), China National Knowledge Infrastructure (CNKI), Wanfang Data, and VIP database for Chinese technical periodicals (VIP) databases. Furthermore, we used CiteSpace and VOSviewer to visualize the annual publications, countries/regions, and keywords. Results] A total of 143 Chinese-language publications and 278 English-language publications were included. Notably, China stood out as the most prolific contributor. Keywords analysis showed that lung cancer, gut microbiota, and immunotherapy were research hotspots in this field. Conclusion] In the past two decades, the vital role of microbiota in the etiology, diagnosis, and treatment of lung cancer has been recognized. Through the comparison of these databases, we found that the hot topics in this field are essentially the same in domestic and foreign. However, this field remains in the early stage, characterized by relatively immature studies and a lack of extensive, close international collaboration. Future studies on the frontier hotspots in this sector need to be strengthened much more. The findings of this study are helpful for researchers to better understand the frontier hotspots and development trends in this area, and provide a reference for the in-depth exploration of future research.