Influence of silver,mercury, lead,cadmium, and selenium on glutathione peroxidase and transferase activities in rats |
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| Authors: | R S Black P D Whanger M J Tripp |
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| Institution: | (1) Department of Agricultural Chemistry, Oregon State University, 97331 Corvallis, Oregon |
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| Abstract: | At the levels used in the experiments, mercury and silver significantly depressed the activity of glutathione peroxidase (assayed
with either H2O2 or cumene-OOH) in rat tissues, whereas cadmium or lead had no effect on this activity. The most pronounced effects of mercury
and silver on glutathione peroxidase were found in the liver and kidneys, with much less effect in the testes and erythrocytes.
Similar trends for the effects of these metals were noted for tissue selenium levels. Silver and mercury significantly depressed
the selenium concentrations, but cadmium and lead had no effect upon the selenium levels. Mercury and silver had no effect
upon the activity of glutathione transferase in liver and testes, but mercury caused a significant initial increase of its
activity in the kidneys. At no time did silver have any significant effect on its activity in this organ. |
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| Keywords: | Glutathione peroxidase effects of Ag Hg Pb Cd and Se on glutathione transferase effects of Ag Hg Pb Cd and Se on Se Ag Hg Pb Cd rats effects of trace metals on glutathione peroxidase and transferase activities in |
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