Neural control of muscle |
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Authors: | Stephen R. Max George J. Markelonis |
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Affiliation: | Departments of Neurology and Anatomy, University of Maryland, School of Medicine, Baltimore, Maryland 21201, U.S.A. |
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Abstract: | Cholinergic innervation regulates the physiological and biochemical properties of skeletal muscle. The mechanisms that appear to be involved in this regulation include soluble, neurally-derived polypeptides, transmitter-evoked muscle activity and the neurotransmitter, acetylcholine, itself. Despite extensive research, the interacting neural mechanisms that control such macromolecules as acetylcholinesterase, the acetylcholine receptor and glucose 6-phosphate dehydrogenase remain unclear. It may be that more simplified in vitro model systems coupled with recent dramatic advances in the molecular biology of neurally-regulated proteins will begin to allow researchers to unravel the mechanisms controlling the expression and maintenance of these macromolecules. |
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Keywords: | AChE acetylcholinesterase AChR acetylcholine receptor, BTX, batrachotoxin ACh acetylcholine ChE cholinesterase TTX tetrodotoxin G6PD glucose 6-phosphate dehydrogenase EDL extensor digitorum longus muscle CAT choline acetyltransferase |
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