Two new polymorphisms in introns 2 and 3 of the human porphobilinogen deaminase gene |
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| Authors: | Makoto Daimon Yoshihiro Morita Keiichi Yamatani Masahiko Igarashi Norio Fukase Hiroshi Ohnuma Kazuhiko Sugiyama Atsushi Ogawa Hideo Manaka Makoto Tominaga Hideo Sasaki |
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| Institution: | (1) Third Department of Internal Medicine, Yamagata University School of Medicine, 2-2-2 Iida-Nishi, 990-23 Yamagata, Japan |
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| Abstract: | Sequencing of the polymerase chain reaction amplified exon 2–4 fragment of the human porphobilinogen deaminase gene revealed a G/T polymorphism (I2G and I2T) in intron 2, and a G/A polymorphism (I3G and I3A) in intron 3 of the gene. The frequencies of these alleles are presented.The nucleotide sequence data reported in this paper (the sequence of introns 2 and 3, and the polymorphic sites) will appear in the DDBJ, EMBL, and GenBank Nucleotide Sequence Database with accession nos. D10608 and D12722 |
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