Ruthenium ammine complexes as electron acceptors for growth stimulation by plasma membrane electron transport |
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Authors: | J -F Laliberté I L Sun F L Crane M J Clarke |
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Affiliation: | (1) Department of Biological Sciences, Purdue University, 47907 West Lafayette, Indiana;(2) Department of Chemistry, Boston College, Chestnut Hill, Massachusetts;(3) Present address: Institut Armand-Frappier, 531 Boul. des Prairies, Laval, Canada |
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Abstract: | Ammineruthenium(III) complexes have been found to act as electron acceptors for the transplasmalemma electron transport system of animal cells. The active complexes hexaammineruthenium(III), pyridine pentaammineruthenium(III), and chloropentaammineruthenium(III) range in redox potential (E
0) from 305 to –42 mV. These compounds also act as electron acceptors for the NADH dehydrogenase of isolated plasma membranes. Stimulation of HeLa cell growth, in the absence of calf serum, by these compounds provides evidence that growth stimulation by the transplasma membrane electron transport system is not entirely based on reduction and uptake of iron. |
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Keywords: | Plasma membrane transmembrane electron transport ruthenium complexes cell growth |
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