A primary screen of the bovine genome for quantitative trait loci affecting twinning rate |
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| Authors: | Sigbjørn Lien Astrid Karlsen Gunnar Klemetsdal Dag Inge Våge Ingrid Olsaker Helge Klungland Monica Aasland Bjørg Heringstad John Ruane Luis Gomez-Raya |
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| Institution: | (1) Department of Animal Science, Agricultural University of Norway, Box 5025, N-1432 Aas, Norway, NO;(2) Department of Morphology, Genetics and Aquatic Biology, The Norwegian School of Veterinary Science, N-0033 Oslo, Norway, NO |
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| Abstract: | An autosomal genome scan for quantitative trait loci (QTL) affecting twinning rate was carried out in the Norwegian Cattle
population. Suggestive QTL were detected on Chromosomes (Chr) 5, 7, 12, and 23. Among these, the QTL positions on both Chr
5 and Chr 23 are strongly supported by literature in the field. Our results also confirm previous mapping of a QTL for twinning
to Chr 7, but definitely suggest a different location of the QTL on this chromosome. The most convincing QTL peak was observed
for a region in the middle part of Chr 5 close to the insulin-like growth factor 1 (IGF1) gene. Since IGF1 plays an important role in the regulation of folliculogenesis, a mutation search was performed by sequencing more than 3.5
kb of the gene in actual families. The sequencing revealed three polymorphisms in noncoding regions of the gene that will
be important in fine structure mapping and characterization of the QTL.
Received: 14 December 1999 / Accepted: 25 May 2000 |
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