A glucose-selective fluorescence sensor based on boronic acid-diol recognition |
| |
| Authors: | Karnati Vishnu Vardhan Gao Xingming Gao Shouhai Yang Wenqian Ni Weijuan Sankar Sabapathy Wang Binghe |
| |
| Institution: | Department of Chemistry, North Carolina State University, Raleigh, NC 27695-8204, USA. |
| |
| Abstract: | A glucose selective diphenylboronic acid fluorescent sensor (10a) with a K(a) of 1472M(-1) has been synthesized and evaluated. This sensor shows a 43- and 49-fold selectivity for glucose over fructose and galactose, respectively. The binding affinity improvement is about 300-fold and the selectivity improvement for glucose over fructose is about 1400-fold compared with the monoboronic acid compound, phenylboronic acid. 1H NMR studies indicate that sensor 10a binds with alpha-D-glucofuranose in a bidentate manner (1:1 ratio). |
| |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
