Neurotrophic Activity of Organosulfur Compounds Having a Thioallyl Group on Cultured Rat Hippocampal Neurons |
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| Authors: | Moriguchi Toru Matsuura Hiromichi Kodera Yukihiro Itakura Yoichi Katsuki Hiroshi Saito Hiroshi Nishiyama Nobuyoshi |
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| Institution: | (1) Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan;(2) Institute for OTC Research, Wakunaga Pharmaceutical Co., Ltd., Hiroshima, Japan |
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| Abstract: | Several organosulfur compounds found in garlic extract promoted the survival of rat hippocampal neurons in vitro. From the analysis of structure-activity relationship, thioallyl group in these compounds is essential for the manifestation of neurotrophic activity. S-Allyl-L-cysteine (SAC), one of the organosulfur compounds having thioallyl group in garlic extract, also promoted the axonal branching of cultured neurons. These results suggest that thioallyl compounds make a unique group of neurotrophic factors. |
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| Keywords: | Garlic thioallyl group rat hippocampus neuronal survival axonal branching |
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