Orchestration of metabolism by macrophages |
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| Authors: | Biswas Subhra K Mantovani Alberto |
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| Institution: | Singapore Immunology Network, Agency for Science, Technology, and Research, #04-06 Immunos, 8A Biomedical Grove, Singapore, Republic of Singapore. subhra_biswas@immunol.a-star.edu.sg |
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| Abstract: | Metabolic adaptation is a key component of macrophage plasticity and polarization, instrumental to their function in homeostasis, immunity, and inflammation. Macrophage products also impact metabolism, as illustrated by obesity-associated pathologies. Defining the mechanisms regulating macrophage metabolic activity and orchestration of metabolism by macrophages is crucial to pathology and therapeutic intervention. |
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