Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal

Authors:	Zarse Kim Schmeisser Sebastian Groth Marco Priebe Steffen Beuster Gregor Kuhlow Doreen Guthke Reinhard Platzer Matthias Kahn C Ronald Ristow Michael

Affiliation:	Department of Human Nutrition, Institute of Nutrition, University of Jena, Jena, Germany.

Abstract:	Download : Download high-res image (241KB) Download : Download full-size image Highlights? Acute impairment of daf-2 (insulin/IGF1) signaling causes a transient ROS signal ? Different antioxidants reduce daf-2-mediated life span extension by up to 60% ? Reduced daf-2 signaling impairs glucose uptake and promotes proline metabolism ? Nutritional supplementation with the amino acid L-proline extends life span

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