Production and fungitoxic activity of Sch 642305, a secondary metabolite of <Emphasis Type="Italic">Penicillium canescens</Emphasis> |
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Authors: | Rosario Nicoletti Maria Pilar Lopez-Gresa Emiliano Manzo Angela Carella Maria Letizia Ciavatta |
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Institution: | (1) C.R.A. - Tobacco Experiment Institute, Via Vitiello 108, Scafati, Italy;(2) Institute of Biomolecular Chemistry, C.N.R, Via Campi Flegrei 36, Pozzuoli, Italy |
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Abstract: | Production of fungitoxic extrolites was evaluated in culture filtrates of several isolates belonging to Penicillium canescens and P. janczewskii that showed some extent of inhibitory activity against the plant pathogenic fungus Rhizoctonia solani. In addition to griseofulvin and dechlorogriseofulvin that are already known in these species, curvulinic acid, previously
unreported in Penicillium, was produced by all isolates assayed. Another extrolite recently characterized from a P. verrucosum strain by the name of Sch 642305 was detected in 5 isolates of P. canescens only. The purified compound completely inhibited mycelial growth of isolates of Rhizoctonia solani and other plant pathogenic fungi in␣vitro. The role of this extrolite as a possible biochemical determinant of antagonism toward plant pathogenic fungi, and implications
concerning chemotaxonomy are discussed. |
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Keywords: | Antagonism Curvulinic acid Fungitoxic extrolites Griseofulvin Penicillium janczewskii |
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