Aucubin modulates Bcl-2 family proteins expression and inhibits caspases cascade in H2O2-induced PC12 cells |
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| Authors: | Hong Yu Xue Dong Yan Niu Gui Zhen Gao Qiu Ye Lin Li Ji Jin Yong Ping Xu |
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| Affiliation: | (1) Department of Chemistry and Life Science, Suzhou University, No. 71 Bianhe Road, Suzhou, 234000, Anhui, People’s Republic of China;(2) Department of Bioscience and Biotechnology, Dalian University of Technology, No. 2 Linggong Road, Ganjingzi, Dalian, 116024, Liaoning, People’s Republic of China;(3) Dalian SEM Bioengineer and Biotech Ltd, No. 58 Life 1 Road, Double-D Harbor, Dalian Hi-tech Industrial Zone, Dalian, 116024, Liaoning, People’s Republic of China;(4) Faculty of Animal Science and Technology, Yunnan Agricultural University, Kunming, People’s Republic of China; |
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| Abstract: | In this study, the effect of aucubin on H2O2-induced apoptosis was studied by using a rat pheochromocytoma (PC12) cell line. We have analyzed the apoptosis of H2O2-induced PC12 cells, H2O2-induced apoptosis appeared to correlate with lower Bcl-2 expression, higher Bax expression and sequential activation of caspase-3 leading to cleavage of poly-ADP-ribose polymerase (PARP). Aucubin not only inhibited lower Bcl-2 expression, high Bax expression, but also modulated caspase-3 activation, PARP cleavage, and eventually protected against H2O2-induced apoptosis. These results indicated that aucubin can obstruct H2O2-induced apoptosis by regulating of the expression of Bcl-2 and Bax, as well as suppression of caspases cascade activation. |
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