The frequency of factor V Leiden mutation,ACE gene polymorphism,serum ACE activity and response to ACE inhibitor and angiotensin II receptor antagonist drugs in Iranians type II diabetic patients with microalbuminuria |
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Authors: | Zohreh Rahimi Vahid Felehgari Mehrali Rahimi Hadi Mozafari Kheirollah Yari Asad Vaisi-Raygani Mansour Rezaei Shohreh Malek-Khosravi Habibolah Khazaie |
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Institution: | (1) The Rhazes Center for Research in Family Health and Sexual Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran;(2) Medical Biology Research Center, Medical School, Kermanshah University of Medical Sciences, Daneshgah Avenue, P.O. Box 67148-69914, Kermanshah, Iran;(3) Department of Biochemistry, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran;(4) Department of Pharmacology, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran;(5) Department of Endocrinology, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran |
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Abstract: | The aim of present study was to determine if factor V Leiden (FVL) mutation and angiotensin converting enzyme insertion/deletion
(ACE I/D) polymorphism are associated with diabetic nephropathy (DN) among Kurdish population from Western Iran. This case–control
study comprised 144 unrelated adult type 2 diabetic mellitus patients (T2DM) including 72 patients with microalbuminuria and
72 age and sex matched patients without nephropathy. The ACE I/D polymorphism and FVL mutation were detected by polymerase
chain reaction (PCR) and PCR–RFLP, respectively. The frequency of FVL G1691A and ACE D allele in T2DM patients with microalbuminuria
were 1.6 and 57%, respectively and in normoalbuminuric T2DM patients were 4.9 and 58.3%, respectively (P > 0.05). ACE genotypes affected on serum ACE activity and a better response to ACE inhibitor therapy (captopril) compared
to angiotensin II receptor antagonist (losartan) was obtained with significant reduction of ACE activity in diabetic patients
without nephropathy carrying DD genotype. However, the beneficial effect of losartan therapy was observed in microalbuminuric
patients with II genotype compared to ID and DD genotypes. |
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