Synthesis and cytotoxic activity of new acridine-thiazolidine derivatives |
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Authors: | Barros Francisco W A Silva Teresinha Gonçalves da Rocha Pitta Marina Galdino Bezerra Daniel P Costa-Lotufo Letícia V de Moraes Manoel Odorico Pessoa Cláudia de Moura Maria Aline F B de Abreu Fabiane C de Lima Maria do Carmo Alves Galdino Suely Lins Pitta Ivan da Rocha Goulart Marilia O F |
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Institution: | Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, Ceará, Brazil. |
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Abstract: | Although their exact role in controlling tumour growth and apoptosis in humans remains undefined, acridine and thiazolidine compounds have been shown to act as tumour suppressors in most cancers. Based on this finding, a series of novel hybrid 5-acridin-9-ylmethylene-3-benzyl-thiazolidine-2,4-diones were synthesised via N-alkylation and Michael reaction. The cell viability was analysed using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and DNA interaction assays were performed using electrochemical techniques. |
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