Prostaglandin D2 inhibits the proliferation of human malignant tumor cells |
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| Authors: | Toshiyuki Sakai Nozomi Yamaguchi Yasuko Shiroko Morimasa Sekiguchi Genshichiro Fujii Hoyoku Nishino |
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| Institution: | 1. Department of Preventive Medicine, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamikyo-ku, Kyoto, 602, Japan;2. Department of Clinical Oncology, Institute of Medical Science, University of Tokyo, 4-6-1 Shiroganedai, Minato-ku, Tokyo, 108, Japan;3. Department of Biochemistry, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamikyo-ku, Kyoto, 602, Japan |
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| Abstract: | The cytotoxic effect of prostaglandin (PG) D2, PGE1 and PGF2α was examined on human osteosarcoma cells (KSu cell line)
, and PGD2 was most effective. DNA, RNA and protein syntheses of KSu cells were also found to be inhibited by PGD2 at a concentration of 5μg/ml. Furthermore, the proliferation of various human malignant tumor cells was inhibited by PGD2 without exception so far. These results suggest that PGD2 shows an antineoplastic effect on a variety of human malignant tumor cells. |
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