内毒素血症大鼠肠道内毒素移位的研究

肠源性内毒素血症是多器官功能衰竭的重要发病因素之一，但肠源性内毒素血症的发病机理迄今尚未阐明，本工作在离体动物，离体大鼠回肠血管灌流标本和分离的小肠粘膜刷状缘微囊制备上，观察到循环血中内毒素正反馈地促进肠道内毒素移位，多种调节肽参与内毒素移位的调控，内皮素促进而心钠素抑制其移位过程，肠道内毒素的移位主要不是通过跨细胞途径，本工作还发现牛磺酸具有抑制肠道素移位，改善内毒素血症动物预后的作用，提示牛磺

Intestinal Endotoxin Translocation in Endotoxemic Rats

It has been known that enterogenic endotoxemia is an important pathogenetic factor in multiple organ failure.However, pathogenetic mechanism of enterogenic endotoxemia is yet unclear.In this work, experiments were performed on intact animal or isolated rat ilea-vascular perfusion apparatus and membrane vesicles produced from the extraction of brush border of rat intestinal mucosa.It is found that circulating endotoxin prompted intestinal endotoxin translocation in a positive feedback manner. Various regulatory peptides modulated the endotoxin translocation:endothelin stimulated and atrial natriuretic peptide inhibited the endotoxin translocation, and the pathway of enterogenic endotoxin translocation is mainly not transcellular, probably paracellular.It is also found that taurine significantly inhibited intestinal endotoxin translocation and protected the animals from endotoxemic injury.