Effect of varying concentrations of linoleic acid on alpha-adrenoceptor responses in spontaneously hypertensive rats |
| |
Authors: | D L Crandall B M Goldstein R J Lozito F H Lizzo P Cervoni |
| |
Affiliation: | Medical Research Division, American Cyanamid Company, Pearl River, New York 10965. |
| |
Abstract: | The effect of increased intake of linoleic acid on the alpha-adrenergic system was assessed by safflower oil supplementation to spontaneously hypertensive rats. Linoleic acid-enriched intake at 5%, 15% and 30% by weight of total food intake for 12 wk was associated with a reduction in resting arterial blood pressure, while heart rate and heart to body weight ratios were similar to control group values. A dose-response analysis to norepinephrine bitartrate administered intravenously indicated a significant reduction in the vascular reactivity to this alpha-adrenergic agonist in all groups given linoleic acid. Direct assessment of alpha-adrenoceptor number (Bmax) and affinity (KD) in cardiac sarcolemma with [3H]-prazosin indicated that receptor binding properties were not affected by linoleic acid intake. Our results suggest that short-term linoleic acid supplementation in the established hypertensive state may lower blood pressure through effects upon alpha-adrenergic reactivity in vascular tissue, without associated effects in cardiac tissue. |
| |
Keywords: | |
|
|