Ultrastructural changes induced by HCG in the Leydig cell of the adult mouse testis |
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Authors: | J Russo F L Sacerdote |
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Institution: | (1) Instituto de Histologia y Embriologia, Facultad de Ciencias Medioas, Universidad Nacional de Cuyo, Mendoza, Argentina;(2) Consejo Nacional de Investigaciones Cientificas y Tecnicas, Argentina |
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Abstract: | Summary Adult mice were treated daily with HCG (human chorionic gonadotropin). The most notable changes were found 24 hours after
the second injection of 100 i.u. Nearly all lipid droplets had disappeared. Mitochondria showed a constriction linking the
two portions of the organelle with widened intracristal spaces. Doughnut-shaped, bifurcated, and elongated mitochondria occurred
commonly; their intracristal spaces were consistently widened. The Golgi complex was well developed. Dense bodies and phagolysosomes
seemed to disappear.
The results indicate that the mitochondrion is the first and most responsive organelle affected by HCG treatment. A hypothesis
is advanced that the mitochondria of the Leydig cell provide the energy required for the lipolytic effect of HCG. |
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Keywords: | Leydig cell Gonadotropins Reproduction Ultrastructure Differentiation |
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