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Isolation and characterization of natural products from plant tissue cultures of Maytenus buchananii |
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| Authors: | James P. Kutney Michael H. Beale Phillip J. Salisbury Kenneth L. Stuart Brian R. Worth Phillip M. Townsley William T. Chalmers Kristina Nilsson Giullo G. Jacoli |
| Affiliation: | 1. Department of Chemistry, The University of British Columbia, Vancouver, B.C., Canada V6T 1Y6;2. Department of Food Science, Faculty of Agricultural Science, The University of British Columbia, Vancouver, B.C., Canada V6T 1W5;3. Laboratory of Biochemical Virology, Agriculture Canada, 6660 N.W. Marine Drive, Vancouver, B.C., Canada V6T 1X2 |
| Abstract: | Explants of Maytenus buchananii were induced to form a callus aid subsequently to form suspension cultures on a wide variety of media. Culture extracts showed cytotoxic activity, but examination by TLC did not indicate the presence of maytansine. Isolation of natural products from a large scale suspension culture led to the identification of polpunonic acid, sitosterol and the cytotoxic triterpene quinone-methides, tingenone and 22β-hydroxytingenone. Possible biosynthetic relationships of these and other triterpene quinone-methides are discussed. |
| Keywords: | Celastraceae tissue culture polpunonic acid sitosterol quinonemethides tingenone 22β-hydroxytingenone. |
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