The use of a prostacyclin analogue, [3H]iloprost,for studying prostacyclin-binding sites on human platelets and neuronal hybrid cells |
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Authors: | Jean M Hall Philip G Strange |
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Institution: | (1) Department of Biochemistry, The Medical School, Queen's Medical Centre, NG7 2UH Nottingham, UK |
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Abstract: | The stable prostacyclin analogue 3H]iloprost has been used for labelling prostacyclin-binding sites on human platelets and NCB-20 neuronal hybrid cells. The ligand-binding properties of the sites have been determined and correlate well with stimulation of cAMP synthesis in NCB-20 cells and inhibition of aggregation in human platelets. |
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