Design, synthesis and structure-activity relationships of 6-O-arylpropargyl diazalides with potent activity against multidrug-resistant Streptococcus pneumoniae |
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| Authors: | Yong Hong Gu Yu Gui Clark Richard F Marron Thomas Ma Zhenkun Soni Niru Stone Gregory G Nilius Angela M Marsh Kennan Djuric Stevan W |
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| Institution: | Infectious Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60044, USA. hong.yong@abbott.com |
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| Abstract: | A novel series of 6-O-arylpropargyl diazalides was synthesized and evaluated for their antibacterial activity. Members of this series exhibited potent activity against erythromycin-resistant respiratory tract pathogens. |
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