Effect of Polysaccharides and Human Plasma Lipoproteins on the Secretion of Cystatin C by Peritoneal Macrophages from Normal and Tumor Bearing Mice |
| |
Authors: | O. N. Poteryaeva L. M. Polyakov T. A. Korolenko T. V. Zueva G. S. Russkikh L. E. Panin |
| |
Affiliation: | Institute of Biochemistry, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk 630117, Russia. ibch@soramn.ru |
| |
Abstract: | Intact peritoneal macrophages in vitro secreted the cysteine proteinase inhibitor cystatin C. Polysaccharides stimulated cystatin C secretion: lipopolysaccharide < carboxymethylated beta-D-glucan < sulfoethylated beta-D-glucan. Human plasma low-density- (LDL) and high-density lipoproteins (HDL) are still more potent inducers of cystatin C secretion by macrophages. Peritoneal macrophages from mice with experimental HA-1 hepatoma compared to those from intact mice secreted more cystatin C with maximum polysaccharide-stimulated secretion after 30 min of incubation. LDL and HDL induced cystatin C secretion by tumor macrophages also. |
| |
Keywords: | cystatin C peritoneal macrophage lipoprotein hepatoma HA-1 |
本文献已被 PubMed SpringerLink 等数据库收录! |