Passive immunization of insulin-like growth factor (IGF)-1 and of IGF-1 and IGF-2 in chickens |
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| Institution: | 1. Organismal Biology, Ecology, and Evolution, University of Montana, Missoula, MT 59812, USA;2. Organismic and Evolutionary Biology, University of Massachusetts Amherst, Amherst, MA 01003, USA;3. Department of Biology, University of Massachusetts Amherst, Amherst, MA 01003, USA |
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| Abstract: | The effects of passive immunization against IGF-1 either alone, or together with immunization against IGF-2, on growth and metabolism were examined in chickens. Immunization against IGF-1 alone had no effect upon any aspect of growth, carcass composition, efficiency of energy utilization or hormone concentrations studied. Immunization against both IGF-1 and IGF-2 together resulted in a lighter final body weight (P < 0.05) compared with controls. Immunization against both IGFs together decreased abdominal fat content (P < 0.05) and resulted in a heavier mean spleen weight (P < 0.01). The joint immunization was also associated with elevated plasma T3 concentrations. These data may indicate a role for IGF-2, but not for IGF-1, in fat metabolism in chickens. |
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