Resistance to Azole Drugs in Neurospora crassa |
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| Institution: | 1. Laboratorio de Investigación en Bacteriología Anaerobia, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica;2. Centro de Investigación en Enfermedades Tropicales, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica;3. Programa de Investigación en Enfermedades Tropicales, Escuela de Medicina Veterinaria, Universidad Nacional, Heredia, Costa Rica;1. Department of Molecular Genetics, The Ohio State University, Columbus, OH 43210, USA;2. Department of Human Sciences, The Ohio State University, Columbus, OH 43210, USA;3. Center for RNA Biology, The Ohio State University, Columbus, OH 43210, USA;1. State Key Laboratory of Microbial Technology, Microbial Technology Institute, Shandong University, No. 72 Binhai Road, Qingdao 266237, China;2. National Glycoengineering Research Center, Shandong University, No. 72 Binhai Road, Qingdao 266237, China;3. Vocational Education College, Dezhou University, Dezhou 253023, China;1. Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil;2. Departamento de Biologia Molecular e Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil;3. Departamento de Ciências Básicas da Saúde, Programa de Pós-Graduação em Biociências, Universidade Federal de Ciências da Saúde de Porto Alegre;4. Instituto Carlos Chagas, Fundação Oswaldo Cruz (Fiocruz), Curitiba, Brazil;5. Instituto de Microbiologia da Universidade Federal do Rio de Janeiro, Brazil;6. Instituto de Química, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil;1. Division of Mycology, Kayseri Education and Research Hospital, Kayseri, Turkey;2. Division of Mycology, Sisli Etfal Hamidiye Education and Research Hospital, Istanbul, Turkey;3. Division of Mycology, Fatih Sultan Mehmet Education and Research Hospital, Istanbul, Turkey;4. Division of Mycology, Kayseri Yunus Emre Hospital, Eskişehir, Turkey;5. Istanbul University, Cerrahpasa Medical Faculty, Department of Microbiology, Istanbul, Turkey |
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| Abstract: | Staben, C. 1995. Resistance to azole drugs in Neurospora crassa. Experimental Mycology 19: 163-165. Neurospora crassa was susceptible to azole drugs: ketoconazole (MIC 1 μg/ml), fluconazole (MIC 5 μg/ml), and SCH39304 (MIC 5 μg/ml). Mutants of N. crassa resistant to ketoconazole were selected and genetically characterized. The seven characterized resistance mutations represented at least four genetic loci. Some mutants, but not all, were also resistant to fluconazole and to SCH39304. |
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