Cyclins of the fission yeast Schizosaccharomyces pombe |
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| Institution: | 1. National Research Council, Institute of Ecosystem Study, Section of Pisa, Via Moruzzi, 1, 56124 Pisa, Italy;2. National Research Council, Institute of Biophysics, Section of Pisa, Via Moruzzi, 1, 56124 Pisa, Italy;3. University of Pisa, Department of Agriculture, Food and Environment, Via del Borghetto, 80, 56124 Pisa, Italy;1. Department of Surgical Pathology, Changhua Christian Hospital, Changhua 50006, Taiwan;2. Department of Medical Technology, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli 35664, Taiwan;3. School of Medicine, Chung Shan Medical University, Taichung 40242, Taiwan;4. Department of Medical Education, Chung Shan Medical University Hospital, Taichung 40242, Taiwan;5. Department of Surgery, Changhua Christian Hospital, Changhua 50006, Taiwan;6. School of Medicine, National Yang Ming University, Taipei 11221, Taiwan;7. Cancer Research Center, Changhua Christian Hospital, Changhua 50006, Taiwan;8. School of Optometry, Chung Shan Medical University, Taichung 40242, Taiwan;9. Institute of Medicine, Chung Shan Medical University, Taichung 40242, Taiwan;10. Department of Gastroenterology, Changhua Christian Hospital, Changhua 50006, Taiwan;11. Department of Medical Oncology and Chest Medicine, Chung Shan Medical University Hospital, Taichung 40242, Taiwan;1. Molecular and Cellular Biology, Roswell Park Cancer Center, Buffalo, NY, USA;2. Department of Pathology, Roswell Park Cancer Center, Buffalo, NY, USA;3. Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, CA, USA |
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| Abstract: | Five cyclin-like genes, cig1, cig2/cyc17, mcs2, puc1 and cdc13, have been discovered in S. pombe to date. It is not yet clear what their functions are or even whether they are all involved with control of the cell cycle. Conflicting data for cig1 and cig2/cyc17 have obscured analysis of their function and cig1 remains largely uncharacterized, although clues to the role of cig2/cyc17 have emerged. There is genetic data available for the more distant cyclin homologue mcs2, which has an essential although as yet unspecified role. Puc1 may be involved in regulation of exit from the cell cycle. The first cyclin to be discovered, and the best understood, is cdc13 which with cdc2 promotes mitosis. Studies of the roles of cdc2 and cdc13 in the overall ordering of the cell cycle suggest that cdc13 and probably other cyclins are key regulators, maintaining the order of S phase and mitosis during the cell cycle. |
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