Intradiscal injection of simvastatin retards progression of intervertebral disc degeneration induced by stab injury |
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| Authors: | Huina Zhang Lin Wang Jun Beom Park Paul Park Victor C Yang Scott J Hollister Frank La Marca Chia-Ying Lin |
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| Affiliation: | (1) Spine Research Laboratory, Department of Neurosurgery, University of Michigan Medical School, 1500 E. Medical Center Drive, Ann Arbor, Michigan 48109, USA;(2) Department of Biomedical Engineering, University of Michigan, 2200 Bonisteel Blvd., Ann Arbor, Michigan 48109-2099, USA;(3) Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, 428 Church Street, Ann Arbor, MI 48109-1065, USA |
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| Abstract: | Introduction Earlier work indicates that the cholesterol-lowering drug, simvastatin, is anabolic to chondrogenic expression of rat intervertebral disc (IVD) cells, which suggests a potential role for simvastatin in IVD regeneration. In this study, we expand on our earlier work to test the effectiveness of simvastatin on disc degeneration utilizing a rat tail disc degeneration model. |
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