Analysis of Streptomyces coelicolor M145 genes SCO4164 and SCO5854 encoding putative rhodaneses |
| |
| Authors: | Tetiana Gren Bohdan Ostash Volodymyr Babiy Ihor Rokytskyy Victor Fedorenko |
| |
| Affiliation: | 1.Department of Genetics and Biotechnology,Ivan Franko National University of Lviv,Lviv,Ukraine;2.Microbial Genomics and Biotechnology, Center for Biotechnology,Bielefeld University,Bielefeld,Germany |
| |
| Abstract: | Streptomyces coelicolor genome carries two apparently paralogous genes, SCO4164 and SCO5854, that encode putative thiosulfate sulfurtransferases (rhodaneses). These genes (and their presumed translation products) are highly conserved and widely distributed across actinobacterial genomes. The SCO4164 knockout strain was unable to grow on minimal media with either sulfate or sulfite as the sole sulfur source. The SCO5854 mutant had no growth defects in the presence of various sulfur sources; however, it produced significantly less amounts of actinorhodin. Furthermore, we discuss possible links between basic interconversions of inorganic sulfur species and secondary metabolism in S. coelicolor. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
