Body weight setpoint, metabolic adaption and human starvation |
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Authors: | Frank P Kozusko |
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Institution: | (1) Department of Mathematics, Hampton University, Hampton, Virginia 23668, USA |
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Abstract: | A biological setpoint for fatness has been proposed in the medical literature. This body weight setpoint functions as a point
of stable equilibrium. In an underfed state, with resulting weight loss, the body will reduce the relative energy expenditure
by metabolic adaption which reduces the rate of weight loss. Previous mathematical models of energy expenditure and weight
loss dynamics have not addressed this setpoint mechanism. The setpoint model has been proposed to quantify this biological
process and is unique in predicting energy expenditure during weight loss as a function of the setpoint fat-free mass ratio
and setpoint energy expenditure, eliminating the various controlling characteristics such as age, gender and heredity. The
model is applied to the seminal Minnesota human semistarvation experiment and is used to predict weight vs time on an individual
basis and the caloric requirements for weight maintenance at the reduced weight. Comparison is made with the Harris-Benedict
equations and the Brody-Kleiber. (W
3/4) law. |
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Keywords: | |
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