A new MspI restriction fragment length polymorphism in the hemophilia B locus |
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| Authors: | G. Camerino I. Oberlé D. Drayna J. L. Mandel |
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| Affiliation: | (1) Unité 184 de Biologie Moléculaire, Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, 11, rue Humann, 67085 Strasbourg Cédex, France;(2) de Génie Génétique de l'INSERM, Faculté de Médecine, 11, rue Humann, 67085 Strasbourg Cédex, France;(3) Departimento di Genetica e Microbiologia, Universita di Pavia, Italy;(4) Howard Hughes Medical Institute, University of Utah Medical Center, Salt Lake City, USA |
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| Abstract: | Summary Using a partial cDNA probe for human coagulation factor IX, we have detected a new restriction fragment length polymorphism in human DNA digested with MspI. The frequency of the minor allele is 0.20±0.05 and average heterozygosity is about 0.32. The MspI RELP is in strong linkage disequilibrium with the TaqI RFLP previously described, but should nevertheless be useful in segregation analysis in case of homozygosity for the TaqI minor allelc. |
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