分子与细胞事件的光学可视化——解读2008年诺贝尔化学奖

绿色荧光蛋白（green fluorescent protein，GFP）及其突变体作为报告基因，已被广泛应用于基因表达调控、蛋白质空间定位、生物分子之间相互作用、转基因动物以及药物药效评价和作用机理研究等方面，极大地推动了现代生物学的发展．随着光电信息技术的不断进步，基于荧光报告基因的光学分子成像技术将在细胞、细胞网络、组织、器官和个体等不同层次实现分子与细胞事件的实时可视化，从而在重大疾病的早期诊断和药物研发中发挥重要作用．

Optical Visualization of Molecular and Cellular Events----To Decode 2008 Nobel Prize in Chemistry

Green Fluorescent Protein (GFP) and its mutants, as reporter genes, are widely applied in the regulation of gene expression, spatial location of protein, interaction between biological molecules, transgenic animal, evaluation of drug effect, and study of drug action mechanism, infinitely promoting the development of modern biology. With the constant progress of optoelectronic information techniques, Optical molecular imaging techniques, based on the fluorescent report genes, will lead to the real time visualization of molecular and cellular events in the different levels such as cell, cell network, tissue, organ, and body, and thus play an important role in the early diagnosis of dread disease as well as drug discovery and development.