Genetic determination of striatal tyrosine hydroxylase activity in mice |
| |
| Authors: | Csaba Vadász Istvan Sziráki Leelavati R Murthy Abel Lajtha |
| |
| Institution: | (1) Laboratory of Neurobehavioral Genetics Neurochemistry Division, Nathan S. Kline Institute for Psychiatric Research, 10962 Orangeburg, New York;(2) Center for Neurochemistry, Nathan Kline Institute Ward's Island, 10035 New York, NY;(3) Present address: Institute for Drug Research, Budapest, Hungary;(4) Present address: New York State Psychiatric Institute, Research Foundation for Mental Hygiene, Inc., 10032 New York, New York |
| |
| Abstract: | An additive major gene effect is described for tyrosine hydroxylase activity in mouse corpus striatum (CS). Quantitative genetic analysis indicated the presence of a segregating Mendelian factor with robust additive effect in F2 generations derived from crossing two highly inbred mouse strains, C57BL/6ByJ and BALB/ cJ, with intermediate (INT) and high (HI) TH activity in CS. Significant positive correlation was found between striatal and mesencephalic TH activity in the segregating generations, raising the possiblity that a common single gene may express its effect through pleiotropy or linkage. Genetic preparations taking advantage of the major gene effect should serve well as animal models of DA-mediated neuropsychiatric disorders. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
