| 实验性肾功能衰竭大鼠血浆中分子物质总量和自由基的变化研究 |
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| 引用本文： | 许涛,钱琛,汪远金. 实验性肾功能衰竭大鼠血浆中分子物质总量和自由基的变化研究[J]. 生物学杂志, 2000, 17(6): 24-24,23 |
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| 作者姓名： | 许涛 钱琛 汪远金 |
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| 作者单位： | 安徽中医学院中西医结合系,合肥,230038 |
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| 摘 要： | 用腺嘌呤复制动物性慢性肾功能衰竭（ＣＲＦ）模型。观察大鼠血浆血尿素氮（ＢｕＮ）、血肌酐（Ｃｒ）、血红蛋白（Ｈｂ）、超氧化物歧化酶（ＳＯＤ）和中分子物质（ＭＭＳ）总量的变化。结果表明，ＣＲＦ大鼠血浆ＢｕＮ、Ｃｒ和ＭＭＳ总量明显升高（Ｐ〈０．０１）、Ｈｂ和ＳＯＤ含量显著降低（Ｐ〈０．０１）。提示ＣＲＦ大鼠ＭＭＳ总量升高、ＳＯＤ活性降低。
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| 关 键 词： | 中分子物质血红蛋白 肾功能衰竭 自由基 血浆 |
| 文章编号： | 1008-9632(2000)06-0024-01 |
Study on the variance of level of plasma middle molecule substance and free radical in rats with experimental chronic renal failure |
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| XU Tao,QIAN Chen,WANG Yuan-jin. Study on the variance of level of plasma middle molecule substance and free radical in rats with experimental chronic renal failure[J]. Journal of Biology, 2000, 17(6): 24-24,23 |
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| Authors: | XU Tao QIAN Chen WANG Yuan-jin |
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| Abstract: | Objective To observe the variance of the sum of hBun,hCr,hHb,hSOD and hMMS(middle molecule substance)in plasma of rats with experimental chronic renal failure.Methods Re-making animal model with adenine in rats with experimental chronic renal failure(CRF).Results The sum of hBun,hCr,and hMMS in plasma of rats with experimental CRF is apparently increased(P<0.01),and that of hHb and hSOD is apparently decreased(p<0.01).Conclude The results indicated that the content of hMMS was apparently increased and the SOD activity was decreased,compared with the normal group. |
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| Keywords: | Middle molecule substance Hemoglobin Blood urea nitrogen creatinin Superoxide dismutase chronic renal failure$ |
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