Association of GSTP1 Ile105Val Polymorphism and Risk of Head and Neck Cancers: A Meta-Analysis of 28 Case-Control Studies |
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| Authors: | Juntian Lang Xicheng Song Jinwei Cheng Shuwei Zhao Jingping Fan |
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| Institution: | 1. Department of Otorhinolaryngology-Head & Neck Surgery, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China.; 2. Department of Otolaryngology-Head and Neck Surgery, Yuhuangding Hospital of Qingdao University, Yantai, China.; 3. Department of Ophthalmology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China.; Harvard Medical School, United States of America, |
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| Abstract: | Background and AimsThe Glutathione S-transferase P1 (GSTP1) polymorphism have been considered a risk modifier for developing head and neck cancer (HNC) in many studies; however, the results of such studies are inconsistent. The aim of this study was to evaluate the possible association between the GSTP1 Ile105Val polymorphism and risk of HNC.MethodWe performed a search in the relevant electronic database and a meta-analysis based on 28 published case–control studies that included 6,404 cases and 6,523 controls. To take into account the possibility of heterogeneity across the studies, a Chi-square based I2-statistic test was performed. Crude pooled odds ratios (ORs) with 95% confidence intervals (CIs) were assessed using both fixed-effects and random-effects models.ResultsThe results of this meta-analysis showed that the GSTP1 Ile105Val polymorphism was not significantly associated with risk of HNC in the overall study population (pooled OR 1.00, 95% CI 0.92–1.09) or in subgroup analyses stratified by ethnicity, sample size, tumor site or publication year. Moreover, substantial evidence of heterogeneity among the studies was observed. Publication year was identified as the main cause of heterogeneity.ConclusionThis meta-analysis does not support a significant association between the GSTP1 Ile105Val polymorphism and risk of HNC. |
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