| 温度对下丘脑神经元膜上延迟整流性K^＋通道活动密度的影响 |
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| 作者姓名： | Cai CQ Zou F Luo BD |
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| 作者单位： | 蔡春青（广州第一军医大学高温医学研究室,广州 510515）;邹飞（广州第一军医大学高温医学研究室,广州 510515） |
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| 基金项目： | 国家自然科学基金资助(39970810）和军队基金资助(98M071） |
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| 摘 要： | 目的：探讨温度对下丘脑神经元延迟整流性K^＋单离子通道（Ik）活动密度的影响。方法：采用膜片钳细胞贴附式技术观察和记录32℃、37℃和39℃时下丘脑神经元Ik的活动。结果：温度升高,记录到封 膜片上Ik活动的机率增大,由32℃时的34.6％升至39℃的51.05,而且出现通道活动;Ik通道活动密度明显增高（P＜0.05）,32℃、37℃和39℃时膜上的通道活动密度分别为0.71、1.22 和1.52channels/μm^2。结论：温度升高,下丘脑神经元上Ik通道更多地处于活动状态,这可能利于丘脑神经元对体温活动的调节。
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| 关 键 词： | 温度 下丘脑神经元 钾通道 活动密度 |
| 文章编号： | 1000-6834(2001)01-0014-04 |
| 修稿时间： | 1999年8月30日 |
Effects of temperature on the open-channel density of delayed rectifier K+ channels in hypothalamic neurons |
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| Cai CQ,Zou F,Luo BD.Effects of temperature on the open-channel density of delayed rectifier K+ channels in hypothalamic neurons[J].Chinese Journal of Applied Physiology,2001,17(1):14-17. |
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| Authors: | Cai C Q Zou F Luo B D |
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| Institution: | Department of Thermal Environmental Medicine, the First Military Medical University, Guangzhou 510515. |
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| Abstract: | AIM AND METHODS: To observe the effect of temperature on multi-order open of delayed rectifier K+ channels in hypothalamic-neurons by cell-attached mode of patch-clamp technique. Results: With temperature raising, the probability of open-channel recording increased, multichannel open occurred. The density of open - channel on membrane of 32 degrees C, 37 degrees C and 39 degrees C was 0.71, 1.22 and 1.82 channels/microm2 respectively (P < 0.05). CONCLUSION: More Ik of hypothalamus opened with temperature raising, this benefited to the body temperature regulation of neurons in hypothalamus. |
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