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Dynamics and mechanisms of quantum dot nanoparticle cellular uptake |
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| Authors: | Yan Xiao Samuel P Forry Xiugong Gao R David Holbrook William G Telford Alessandro Tona |
| Affiliation: | (1) Chemical Science and Technology Laboratory, National Institute of Standards and Technology (NIST), Gaithersburg, MD, USA;(2) Research and Development, Translabion, Clarksburg, MD, USA;(3) Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA;(4) Science Applications International Corporation (SAIC), Arlington, VA, USA |
| Abstract: | BackgroundThe rapid growth of the nanotechnology industry and the wide application of various nanomaterials have raised concerns over their impact on the environment and human health. Yet little is known about the mechanism of cellular uptake and cytotoxicity of nanoparticles. An array of nanomaterials has recently been introduced into cancer research promising for remarkable improvements in diagnosis and treatment of the disease. Among them, quantum dots (QDs) distinguish themselves in offering many intrinsic photophysical properties that are desirable for targeted imaging and drug delivery. |
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