A bacterial inhibitor of animal protein kinases |
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| Authors: | Mustapha Dadssi Dr Alain J Cozzone |
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| Institution: | (1) Institut de Biologie et Chimie des Protéines, C.N.R.S., Université de Lyon, 69622 Villeurbanne, France |
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| Abstract: | Cellular extracts ofEscherichia coli severely impair the protein-phosphorylating activity in vitro of animal enzymes of both the casein-kinase type and the histone-kinase type. This blockade is due to a protein, probably dimeric, acting as a noncompetitive inhibitor, which has been purified to near-homogeneity from the soluble fraction of bacterial cells by chromatographic procedures. |
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